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Precision Oncology & Translational Innovation: Journal of Cancer Science & Therapeutics is a peer-reviewed, open-access journal committed to advancing research, clinical innovation, and therapeutic development in oncology. The journal offers a global platform for publishing original investigations, systematic reviews, translational studies, biomarker development, clinical trials, and technology-enabled therapeutic strategies that tackle cancer at molecular, cellular, and system levels.

Our mission is to accelerate the translation of cutting-edge cancer science into effective patient-centred therapies, while promoting data-driven innovation, interdisciplinary collaboration, and global access. We invite contributions from oncologists, cancer biologists, translational scientists, biomedical engineers, data scientists, and healthcare system innovators. The journal is dedicated to rigorous peer review, transparent publishing, and wide dissemination to enhance cancer care outcomes worldwide.

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Targeting Metabolism and Disulfidptosis: A Novel strategy for Cancer Therapy

Bowen Zheng, Jiabang Yang, Riyu Niu, Jun Xu and Mingpai Ge

Abstract Disulfidptosis represents a recently characterized form of programmed cell death driven by an intracellular imbalance between cystine and the vital reductant Nicotinamide Adenine Dinucleotide Phosphate (NADPH). This metabolic perturbation precipitates an excessive accumulation of disulfide bonds within cytoskeletal proteins, ultimately compromising cellular integrity and inducing death. Specifically, under conditions

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