Targeting Metabolism and Disulfidptosis: A Novel strategy for Cancer Therapy

Abstract Disulfidptosis represents a recently characterized form of programmed cell death driven by an intracellular imbalance between cystine and the vital reductant Nicotinamide Adenine Dinucleotide Phosphate (NADPH). This metabolic perturbation precipitates an excessive accumulation of disulfide bonds within cytoskeletal proteins, ultimately compromising cellular integrity and inducing death. Specifically, under conditions